The Migliaccio Laboratory is involved in two major areas of research.
1.) Pathobiology of Primary Myelofibrosis
Our laboratory discovered that the hypomorphic Gata1low mutation, by impairing megakaryocytic development, induces myelofibrosis in mice. This animal model was the basis for a scientific project included in a Program Project on myeloproliferative disorders funded by the National Cancer Institute.
2.) Translational Research in Transfusion Medicine
Our laboratory applies knowledge on the biology of human erythroid cells to identify drugs that may treat Sickle Cell Anemia and/or Thalassemia and to develop processes to produce red cell transfusion products ex-vivo.
The first project is currently funded by a career development award from New York state.
Perrotta S, Cucciolla V, Ferraro M, Ronzoni L, Tramontano A, Rossi F, Scudieri AC, Borriello A, Roberti D, Nobili B, Cappellini MD, Oliva A, Amendola G, Migliaccio AR, Bertolini F, Prchal J, Della Ragione F. EPO receptor gain-of-function causes hereditary polycythemia, alters CD34 cell differentiation and increases circulating endothelial precursors. Plos One. 2010 Aug 5;5(8).
Verrucci M, Pancrazzi A, Aracil M, Martelli F, Guglielmelli P, Zingariello M, Ghinassi B, D'Amore E, Jimeno J, Vannucchi AM, Migliaccio AR. CXCR4-independent rescue of the myeloproliferative defect of the Gata1low myelofibrosis mouse model by Aplidin. J Cell Physiol. 2010; Nov;225(2):490-9.
Zingariello M, Fabucci ME, Bosco D, Migliaccio AR, Martelli F, Rana RA, Zetterberg E. Differential localization of P-selectin and von Willebrand factor during megakaryocyte maturation. Biotech Histochem. 2010; 85:157-70.
Varricchio L, Mancini A, Migliaccio AR. Pathological interactions between hematopoietic stem cells and their niche revealed by mouse models of primary myelofibrosis. Expert Rev Hematol. 2009; 2:315-334.
Kozma GT, Martelli F, Verrucci M, Gutiérrez L, Migliaccio G, Sanchez M, Alfani E, Philipsen S, Migliaccio AR. Dynamic regulation of Gata1 expression during the maturation of conventional dendritic cells. Exp Hematol. 2010; 38:489-503.
Migliaccio G, Migliaccio AR. Getting personal with B19 parvovirus. Blood. 2010; 115:922-3.
Ghinassi B, Martelli F, Verrucci M, D'Amore E, Migliaccio G, Vannucchi AM, Hoffman R, Migliaccio AR. Evidence for organ-specific stem cell microenvironments. J Cell Physiol. 2010; 223:460-70.
Migliaccio G, Sanchez M, Masiello F, Tirelli V, Varricchio L, Whitsett C, Migliaccio AR. Humanized culture medium for clinical expansion of human erythroblasts. Cell Transplant. 2010; 19:453-69.
Varricchio L, Fabucci ME, Alfani E, Godbold J, Migliaccio AR. Compensated variability in the expression of globin-related genes in erythroblasts generated ex vivo from different donors. Transfusion. 2010;50:672-84.
Ghinassi B, Martelli F, Verrucci M, D’Amore E, Migliaccio G, Vannucchi AM, Hoffman R, Migliaccio AR. Evidence for organ-specific stem cell microenvironments. J Cell Physiol. 2010;223:460-70.