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Dimitris G. Placantonakis

Dimitris G.
Placantonakis
MD, PhD
Assistant Professor
Neurosurgery
Neurosurgical Laboratory for Stem Cell Research
New York University School of Medicine
Director
dimitris.placantonakis@nyumc.org

Our laboratory studies stem cell function in the context of gliomagenesis and neuropsychiatric disorders. Using primary stem cell cultures from human brain tumor specimens, we employ genetic approaches to identify distinct classes of cancer stem cells and the lineages they generate. In addition, we are developing models for glioma formation and psychotic disorders based on human pluripotent stem cells.

Select Publications: 

Tokcaer-Keskin, Z. & Placantonakis, D.G. 2012. Genetic identification of human embryonic stem cell-derived neural cell types using bacterial artificial chromosomes. In Stem Cells and Cancer Stem Cells: Therapeutic Applications in Disease and Injury (ed. M.A. Hayat). Springer, New York, NY.

Placantonakis, D. G., Tomishima, M. J., Lafaille, F., Desbordes, S., Jia, F., Socci, N., Viale, A., Lee, H., Harrison, N., Studer, L. & Tabar, V.  2009.  Enriched motor neuron populations derived from BAC-transgenic human embryonic stem cells.  Clinical Neurosurgery 56:125-132.

Placantonakis, D. G., Tomishima, M. J., Lafaille, F., Desbordes, S., Jia, F., Socci, N., Viale, A., Lee, H., Harrison, N., Tabar, V. & Studer, L.  2009.  BAC transgenesis in human ES cells as a novel tool to define the human neural lineage.  Stem Cells. 27:521-532.

Placantonakis, D. G., Tomishima, M. J., Lafaille, F. G. & Studer, L.  2009.  Genetic manipulation of human embryonic stem cells.  In Regulatory Networks in Stem Cells. (ed. R. Vinagolu & V. Mohan).  Humana Press, Totowa, NJ.

Desbordes, S. C., Placantonakis, D. G., Ciro, A., Socci,, N. D., Lee, G., Djaballah, H. & Studer, L. 2008.  High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells.  Cell Stem Cell. 2:602-612.

Placantonakis, D. G., Bukovsky, A. A., Kiem, H.-P. & Welsh, J. P.  2006.  Continuous electrical oscillations emerge from a coupled network: A study of the inferior olive using lentiviral knockdown of connexin36. Journal of Neuroscience. 26:5008-5016.

Placantonakis, D. G., Bukovsky, A. A., Zeng, X.-H., Kiem, H.-P. & Welsh, J. P.  2004.  Fundamental role of inferior olive connexin 36 in muscle coherence during tremor.  Proceedings of the National Academy of Sciences of the USA. 101:7164-7169.

Placantonakis, D. G., Cicirata, F. & Welsh, J. P.  2002.  A dominant negative mutation of neuronal connexin 36 that blocks intercellular permeability.  Molecular Brain Research. 98, 15-28.

Placantonakis, D. G. & Welsh, J. P.  2001.  Two distinct oscillatory states determined by the NMDA receptor in rat inferior olive.  Journal of Physiology (London). 534, 123-140.

Placantonakis, D. G., Schwarz, C. & Welsh, J. P.  2000.  Serotonin suppresses subthreshold and suprathreshold oscillatory activity of rat inferior olivary neurones in vitro.  Journal of Physiology (London). 524, 833-851.

Placantonakis, D. G., Tomishima, M. J., Lafaille, F. G. & Studer, L.  2009.  Genetic manipulation of human embryonic stem cells.  In Regulatory Networks in Stem Cells. (ed. R. Vinagolu & V. Mohan).  Humana Press, Totowa, NJ.