Professor Linhardt's laboratory specializes in glycobiology, glycochemistry and glycotechnology. They are experts in glycosaminoglycans and proteoglycans found in the extracellular matrix, having critical roles in cell adhesion, migration, differentiation and signaling. The laboratory has had an integral role in understanding the structure-activity of the signal transduction complex. Linhardt's team is actively involved in glycomics research specifically aimed at understanding how glycome changes with stem cell differentiation. This work in nano-biotechnology has involved the separation of carbohydrate-nanomaterial composites with specific chemical, mechanical and electrical properties for optimal interaction with mammalian cells, with the goal of preparing functionalized matrices to control cell differentiation.
Nairn, A. V., Kinoshita-Toyoda, A., Toyoda, H., Xie, J., Harris, K., Dalton, S., Kulik, M., Pierce, J. M., Toida, T., Moremen, K. W., Linhardt, R. J. (2007) Glycomics of Proteoglycan Biosynthesis in Murine Embryonic Stem Cell Differentiation. Journal of Proteome Research 6, 4374-4387.
Goetz, R., Beenken, A., Ibrahimi, O. A., Kalinina, J., Olsen, S. K., Eliseenkova, A. V., Xu, C. F., Neubert, T., Zhang, F., Linhardt, R. J., Yu, X., White, K. E., Inagaki, T., Kliewer, S. A., Yamamoto, M., Kurosu, H., Ogawa, Y., Kuro-o, M., Lanske, B., Razzaque, M. S., Mohammadi, M. (2007) Molecular Insights into the Klotho-Dependent, Endocrine Mode of Action of FGF19 Subfamily Members. Molecular and Cellular Biology, 27, 3417-3428.
Linhardt, R.J., Toida, T. (2004) Role of Glycosaminoglycans in Cellular Communication. Accounts of Chemical Research, 37, 431-438.