Sally Temple, PhD, is the Co-Founder and Scientific Director of the Neural Stem Cell Institute located in Rensselaer, NY. Dr. Temple’s group is focused on studying neural stem cells, and using this knowledge to develop therapies for central nervous system (CNS) disorders.
In 1989, Dr. Temple discovered that the embryonic mammalian brain contained a rare, multipotent stem cell that could be extracted and grown in tissue culture to produce both neurons and glia. Her group has continued to make pioneering contributions to the field of neural stem cell research, identifying factors intrinsic to these cells as well as external signaling molecules from the niche that participate in their self-renewal and differentiation. Recently, she helped identify a novel, accessible adult human CNS stem cell in the retinal pigment epithelium, which offers the possibility of developing therapeutics for retinal disease.
- Kokovay E, Wang Y, Kusek GK, Wurster R, Lederman P, Lowry N, Shen Q, Temple S (2012) VCAM1 is essential to maintain the structure of the SVZ niche and acts as an environmental sensor to regulate SVZ lineage progression. Cell Stem Cell 11:220-230
- Kusek G, Campbell M, Doyle F, Tenenbaum SA, Kiebler M, Temple S (2012) Segregation of the double-stranded RNA binding protein Stau2 during mammalian asymmetric neural stem cell division promotes lineage progression and differentiation. Cell Stem Cell 11:505-16
- Salero E, Blenkinsop TA, Corneo B, Harris A, Rabin D, Stern JH, Temple S (2012). Adult Human RPE can be activated into a multipotent stem cell that produces mesenchymal derivatives. Cell Stem Cell 10:88-95