Barry S. Coller, M.D.

VP for Medical Affairs & Physician-in-Chief
David Rockefeller Professor Allen & Frances Adler Laboratory of Blood & Vascular Biology
Rockefeller University, The
collerb@rockefeller.edu

Dr. Coller's laboratory is developing Platelet Therapy using ES Cell-Derived Megakaryocytes. The ability to generate multiple cell types from embryonic stem (ES) cells in culture offers an unprecedented opportunity to generate an unlimited supply of cells for transplantation for the treatment of a broad range of diseases. Patients treated with chemotherapy or radiation therapy commonly require platelet transfusions and some patients eventually develop reactions to transfused platelets. Thus, a source of platelets derived from embryonic stem cells would be very valuable, especially if they could be prepared with the same tissue type as the recipient. Dr. Coller aims to optimize the differentiation of embryonic stem cells into platelets and to develop animal models to assess their function.

Select Publications

Mitchell, W.B., Li, J., Murcia, M., Valentin, N., Newman, P.J., Coller, B.S. Mapping early conformational changes in aIIbb3 during biogenesis reveals a potential mechanism for aIIbb3 adopting its bent conformation. Blood 109:3725-3732, 2007.

French DL, Jirouskova M, Kennedy M, Coller BS, Keller G.
Generation of Megakaryocytes from Human Embryonic Stem Cells, Abstract, Blood 110, 2007.