Gerold Feuer, Ph.D.

Associate Professor, Microbiology & Immunology
Founder and Director, Humanized SCID Mouse Center
State University of New York Upstate Medical University
feuerg@upstate.edu

Dr. Feuer has employed human hematopoietic stem and progenitor cells (HSC/ HPCs) in his research since 1992. His particular expertise involves generating "humanized" SCID mice (SCID-hu) by intravenous injection of human HSC/HPCs. These mice support the development and maturation of a human immune system comprising T-and B-lymphocytes as well as monocyte/macrophages. SCID-hu mice can be infected with human oncogenic viruses and serve as a unique small animal model to study how viral infection predisposes human stem cells to become leukemic.  Dr. Feuer plans to utilize human embryonic stem cells (hESCs) to evaluate the differentiation profiles following injection into humanized SCID mice.

Select Publications

Banerjee P,Sieburg M,Samuelson E and Feuer G: HTLV-1 Infection of CD34+ Hematopoietic Progenitor Cells Induces Cell Cycle Arrest by Modulation of p21cip1/waf1 and Survivin. Stem Cells, In Press

Wu W, Vieira J, Fiore N, Banerjee P, Sieburg M, Rochford R, Harrington W Jr, Feuer G. KSHV/HHV-8 infection of human hematopoietic progenitor (CD34+) cells: persistence of infection during hematopoiesis in vitro and in vivo.  Blood. 2006 Jul 1;108(1):141-51. Epub 2006 Mar 16.

Tripp A, Banerjee P, Sieburg M, Planelles V, Li F, Feuer G. Induction of cell cycle arrest by human T-cell lymphotropic virus type 1 Tax in hematopoietic progenitor (CD34+) cells: modulation of p21cip1/waf1 and p27kip1 expression.  J Virol. 2005 Nov;79(22):14069-78.