Ali H. Brivanlou, Ph.D.

Professor, Head of the Molecular Embryology Laboratory

Rockefeller University, The
brvnlou@rockefeller.edu

The Brivanlou Laboratory aims to identify the molecular factors that regulate germ layer specification in human embryonic stem cells (hESCs) by testing candidate pathways previously described in model organisms, and by developing screens to identify novel molecules implicated in early human differentiation. In addition, they aim to identify genes implicated in the self-renewal pluripotency of hESCs in culture by analyzing the transcriptional profiles of hESCs in various experimental paradigms, and conducting screens to isolate factors that promote self-renewal. The overall aim is to use hESCs as windows to the study of early human embryonic development.

Select Publications

Spagnoli, F. and Brivanlou, A.H. (2006).  Guiding embryonic stem cells towards differentiation:  lessons from molecular embryology.  Current Opinion in Genetics and Development, 16(5):  469-75. 

Tabibzadeh, S., and Brivanlou, A.H. (2006).  Lefty at the crossroads of "stemness" and differentiative events.  Stem Cells, 24(9):  1998-2006.

James, D. Noggle, S.A., Swigut, T., and Brivanlou, A.H. (2006). Contribution of human embryonic stem cells to mouse blastocysts. Developmental Biology, 295(1):90-102.