Professor Papaioannou is studying the genetic control of early mammalian development, from the first cleavage of the fertilized zygote through implantation, gastrulation, and early organogenesis. The lab uses mouse embryonic stem cells to produce mutations by genetic engineering. In addition, two projects in the Papaioannou lab are related directly to stem cells. One is the derivation of human stem cell lines from clinically dead human embryos obtained from in-vitro fertilization centers. The second is testing the potential of mouse embryo pancreatic stem cell/precursors in the treatment of type 1 diabetes using a mouse model.
Begum, S., Papaioannou, V. E. and Gosden, R. G. 2008. The oocyte population is not renewed in transplanted or irradiated adult ovaries. Human Reproduction doi: 10.1093/humrep/den249.
Gavrilov, S., Prosser, R. W., Khalid, I., Macdonald, J., Sauer, M. V., Landry, D. W. and Papaioannou, V. E. 2008. Irreversibly arrested nonviable (organismically dead) human embryos as a source of viable cells for human embryonic sterm cell (hESC) derivation. Reproductive Biomedicine Online (in press).
Hadjantonakis AK, Pisano E, Papaioannou VE. Tbx6 regulates left/right patterning in mouse embryos through effects on nodal cilia and perinodal signaling. PLoS ONE. 2008 Jun 25;3(6):e2511.