Several lines of evidence argue for the existence of a subpopulation of quiescent leukemia stem cells (LSC) or leukemia initiating cells (LIC) that fail to be killed by chemotherapeutic agents that work best on dividing cells. Therefore, knowledge of the regulation of LSC quiescence holds great therapeutic value. Using a combination of mouse genetics and chemical genetics approaches, our lab is in a unique position to elucidate the mechanism of MECOM in LSC regulation, and to target its protein:DNA interaction, as well as its protein complex with small molecule inhibitors, and hopefully develop a series of novel and effective therapies for acute myeloid leukemia.
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|Arshad M, Ye Z, Gu X, Wong CK, Liu Y, Li D, Zhou L, Zhang Y, Bay WP, Yu VC, Li P. "RNF13, a RING finger protein, mediates endoplasmic reticulum stress-induced apoptosis through the inositol-requiring enzyme (IRE1?)/c-Jun NH2-terminal kinase pathway." The Journal of biological chemistry. 2013 Mar 22; 288(12):8726-36. Epub 2013 Feb 01.|
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|Zhang Y, Sicot G, Cui X, Vogel M, Wuertzer CA, Lezon-Geyda KA, Wheeler JC, Harki DA, Muzikar KA, Stolper DA, Dervan PB, Perkins AS. "Targeting a DNA binding motif of the EVI1 protein by a pyrrole-imidazole polyamide." Biochemistry. 2011 50(48):10431-41. Epub 2011 Nov 10.|