Yi (Stanley) Zhang
Several lines of evidence argue for the existence of a subpopulation of quiescent leukemia stem cells (LSC) or leukemia initiating cells (LIC) that fail to be killed by chemotherapeutic agents that work best on dividing cells. Therefore, knowledge of the regulation of LSC quiescence holds great therapeutic value. Using a combination of mouse genetics and chemical genetics approaches, our lab is in a unique position to elucidate the mechanism of MECOM in LSC regulation, and to target its protein:DNA interaction, as well as its protein complex with small molecule inhibitors, and hopefully develop a series of novel and effective therapies for acute myeloid leukemia.
Zhang Y, Stehling-Sun S, Lezon-Geyda K, Juneja SC, Coillard L, Chatterjee G, Wuertzer CA, Camargo F, Perkins AS. "PR-domain-containing Mds1-Evi1 is critical for long-term hematopoietic stem cell function." Blood. 2011 Oct 6; 118(14):3853-61.
Zhang Y, Sicot G, Cui X, Vogel M, Wuertzer CA, Lezon-Geyda KA, Wheeler JC, Harki DA, Muzikar KA, Stolper DA, Dervan PB, Perkins AS. "Targeting a DNA binding motif of the EVI1 protein by a pyrrole-imidazole polyamide." Biochemistry. 2011 50(48):10431-41.
Cirone P, Lin S, Griesbach HL, Zhang Y, Slusarski DC, Crews CM. "A role for planar cell polarity signaling in angiogenesis." Angiogenesis. 2008 11(4):347-60. Epub 2008 Sep 17.
Zhang Y, Yeh JR, Mara A, Ju R, Hines JF, Cirone P, Griesbach HL, Schneider I, Slusarski DC, Holley SA, Crews CM. "A chemical and genetic approach to the mode of action of fumagillin." Chemistry & biology. 2006 Sep 0; 13(9):1001-9.
Yeh JR, Ju R, Brdlik CM, Zhang W, Zhang Y, Matyskiela ME, Shotwell JD, Crews CM. "Targeted gene disruption of methionine aminopeptidase 2 results in an embryonic gastrulation defect and endothelial cell growth arrest." Proceedings of the National Academy of Sciences of the United States of America. 2006 Jul 5; 103(27):10379-84.
Zhang Y, Qiu WJ, Chan SC, Han J, He X, Lin SC. "Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways." The Journal of biological chemistry. 2002 May 17; 277(20):17706-12.
Zhang Y, Qiu WJ, Liu DX, Neo SY, He X, Lin SC. "Differential molecular assemblies underlie the dual function of Axin in modulating the WNT and JNK pathways." The Journal of biological chemistry. 2001 Aug 24; 276(34):32152-9.