The long-term goal of the Hadjantonakis laboratory is to understand the critical events underlying cell lineage specification and morphogenesis in the mammalian embryo. Central to this goal is the identification of stem and progenitor cell populations resident within the early embryo. In parallel they are also investigating the reprogramming of differentiated cells. To address these questions they are using tools of mouse functional genomics, including transgenesis and targeted mutagenesis in embryonic stem (ES) cells and mice, microarray analysis and optical imaging.
Nowotschin S, Hadjantonakis AK. Use of KikGR a photoconvertible green-to-red fluorescent protein for cell labeling and lineage analysis in ES cells and mouse embryos. BMC Dev Biol. 2009 Sep 9;9:49.
Nowotschin S, Eakin GS, Hadjantonakis AK. Dual transgene strategy for live visualization of chromatin and plasma membrane dynamics in murine embryonic stem cells and embryonic tissues. Genesis. 2009 May;47(5):330-6
Kwon GS, Viotti M, Hadjantonakis AK. The endoderm of the mouse embryo arises by dynamic widespread intercalation of embryonic and extraembryonic lineages. Dev Cell. 2008 Oct;15(4):509-20.
Plusa B, Piliszek A, Frankenberg S, Artus J, Hadjantonakis AK. Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst. Development. 2008 Sep;135(18):3081-91.
Hadjantonakis AK, Pisano E, Papaioannou VE. Tbx6 regulates left/right patterning in mouse embryos through effects on nodal cilia and perinodal signaling. PLoS ONE. 2008 Jun 25;3(6):e2511.
Kwon GS, Hadjantonakis AK. Eomes::GFP-a tool for live imaging cells of the trophoblast, primitive streak, and telencephalon in the mouse embryo. Genesis. 2007 Apr;45(4):208-17.