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Christoph Hansis

Christoph Hansis
M.D., Ph.D.
Assistant Professor
Department of Obstetrics & Gynecology
New York University School of Medicine

For more than 10 years Dr. Hansis investigated the molecular mechanisms defining totipotency, cell differentiation and reprogramming in humans. Based on this experience, his lab now studies human stem cells and their potential application for therapeutic purposes. The establishment of new efficient protocols for derivation of novel human embryonic stem cell lines, as well as the generation of new disease models based on mutation-carrying human embryonic stem cells, promises to advance the study of diseases and the development of new treatment options. Furthermore, investigation into reprogramming mechanisms for stem cells from human cord blood could lead to the derivation of the full equivalent of embryonic stem cells from non-embryonic sources.

Select Publications: 

Hansis C., Totipotency, cell differentiation and reprogramming in humans. Reproductive BioMedicine Online 2006, 13:551-557.

Edwards RG, Hansis C. Initial differentiation of blastomeres in 4-cell human embryos and its significance for early embryogenesis and implantation. Reprod Biomed Online. 2005 Aug;11(2):206-18. Review.

Hansis C, Barreto G, Maltry N, Niehrs C. Nuclear reprogramming of human somatic cells by xenopus egg extract requires BRG1. Curr Biol. 2004 Aug 24;14(16):1475-80.

Hansis C, Grifo JA, Krey LC. Candidate lineage marker genes in human preimplantation embryos.  Reprod Biomed Online. 2004 May;8(5):577-83.

Spiess AN, Walther N, Miller N, Balvers M, Hansis C, Ivell R. SPEER--a new family of testis-specific genes from the mouse. Biol Reprod. 2003 Jun;68(6):2044-54.

Hansis C, Edwards RG. Cell differentiation in the preimplantation human embryo.  Reprod Biomed Online. 2003 Mar;6(2):215-20. Review.

Hansis C, Grifo JA, Tang Y, Krey LC. Assessment of beta-HCG, beta-LH mRNA and ploidy in individual human blastomeres. Reprod Biomed Online. 2002 Sep-Oct;5(2):156-61.

Hansis C, Tang YX, Grifo JA, Krey LC. Analysis of Oct-4 expression and ploidy in individual human blastomeres. Mol Hum Reprod. 2001 Feb;7(2):155-61.

Hansis C, Grifo J. Tay-Sachs disease and preimplantation genetic diagnosis. Adv Genet. 2001;44:311-5. Review. No abstract available.

Hansis C, Grifo JA, Krey LC. Oct-4 expression in inner cell mass and trophectoderm of human blastocysts. Mol Hum Reprod. 2000 Nov;6(11):999-1004.

Hansis C, Jhner D, Spiess AN, Boettcher K, Ivell R. The gene for the Alzheimer-associated beta-amyloid-binding protein (ERAB) is differentially expressed in the testicular Leydig cells of the azoospermic by w/w(v) mouse. Eur J Biochem. 1998 Nov 15;258(1):53-60.

Hansis C, Jhner D, Spiess AN, Ivell R. Differential display PCR cloning of W/Wv-mutant testis specific genes. Adv Exp Med Biol. 1997;424:147-9. No abstract available.