An increasing number of neurological diseases are thought to be caused or exacerbated by defects in glial cells. Consequently, Professor Proschel has focused on the study of glial precursor cells. His research program encompasses three distinct yet complementary areas of interest: the cell-biological analysis of neurological diseases with an emphasis on the role of neural precursors, the molecular analysis of the astrocyte lineage (including signals that promote the generation of astrocyte precursors and distinct classes of astrocytes), and the application of glial progenitors and their derivatives for treatment of neurological diseases, including spinal cord injury.
Davies JE, Proschel C, Zhang N, Noble M, Mayer-Proschel M, Davies SJ. Transplanted astrocytes derived from BMP- or CNTF-treated glial-restricted precursors have opposite effects on recovery and allodynia after spinal cord injury. J Biol. 2008 Sep 19;7(7):24.
Li Z, Dong T, Proschel C, Noble M. Chemically diverse toxicants converge on Fyn and c-Cbl to disrupt precursor cell function. PLoS Biol. 2007 Feb;5(2):e35.
Davies JE, Huang C, Proschel C, Noble M, Mayer-Proschel M, Davies SJ. Astrocytes derived from glial-restricted precursors promote spinal cord repair. J Biol. 2006;5(3):7. Epub 2006 Apr 27.