The adult mammalian brain contains neural stem and progenitor cells that can proliferate, self-renew, and generate all of the cellular elements of the brain including neurons. During the past few years techniques have been developed which make it possible to isolate and expand, from developing or even adult CNS tissue, cells with properties characteristic of early neural multipotent progenitor or stem cells. These techniques have opened interesting new possibilities for the use of cells for CNS transplantation, neural replacement and brain repair. Rosenbaum's lab is initiating a project which will potentially bring the rapidly expanding area of progenitor cells to bear on the problems of stroke and cerebral ischemia.
Berger S, Savitz SI, Nijhawan S, Singh M, David J, Rosenbaum PS, Rosenbaum DM. Deleterious role of TNF-alpha in retinal ischemia-reperfusion injury. Invest Ophthalmol Vis Sci. 2008 Aug;49(8):3605-10.
Jasmin JF, Malhotra S, Singh Dhallu M, Mercier I, Rosenbaum DM, Lisanti MP. Caveolin-1 deficiency increases cerebral ischemic injury. Circ Res. 2007 Mar 16;100(5):721-9. Epub 2007 Feb 9.