Using a novel direct-writing method at RPI, Dr. Corr is fabricating combinatorial libraries of scaffold, biomolecule, and stem cell constructs with single-cell spatial resolution. These tissue-constructs, with varying composition and geometry, will define stem cell properties, leading to custom-designed tissue replacements built with autologous cells. The lab is working to characterize effects of physical/ biochemical stimuli on stem cells, and how these factors direct their differentiation and development to build stem cells into improved prototype tissue replacement constructs.
Aarimaa V, Rantanen J, Best T, Schultz E, Corr D, Kalimo H. Mild eccentric stretch injury in skeletal muscle causes transient effects on tensile load and cell proliferation. Scan J Med Sci Sports 2004; 14(6):367-372.
Best TM, Shehadeh SE, Leverson GE, Michel JT, Corr DT, Aeschlimann D. Analysis of changes in mRNA levels of myoblast- and fibroblast-derived gene products in healing skeletal muscle using quantitative reverse transcription-polymerase chain reaction. J Orthop Res 2001; 19:565- 572.