The mouse has proven to be an invaluable organism for investigation of the immune system. Significant differences with the human immune system have led to several missteps in translational efforts, however. Therefore, Dr. Sant'Angelo is interested in generating mouse models that have fully humanized immune systems. Secondly, Sant'Angelo's lab is interested in the potential of modifying T-cell activities via gene transfer in an effort to enhance or limit immune responses.
Kovalovsky D, Uche OU, Eladad S, Hobbs RM, Yi W, Alonzo E, Chua K, Eidson M, Kim HJ, Im JS, Pandolfi PP, Sant'angelo DB. The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions. Nat Immunol. 2008 Jul 27. [Epub ahead of print]
Zakrzewski JL, Suh D, Markley JC, Smith OM, King C, Goldberg GL, Jenq R, Holland AM, Grubin J, Cabrera-Perez J, Brentjens RJ, Lu SX, Rizzuto G, Sant'Angelo DB, Riviere I, Sadelain M, Heller G, Zooiga-Pflocker JC, Lu C, van den Brink MR. Tumor immunotherapy across MHC barriers using allogeneic T-cell precursors. Nat Biotechnol. 2008 Apr;26(4):453-61. Epub 2008 Mar 30.
Rivera A, Ro G, Van Epps HL, Simpson T, Leiner I, Sant'Angelo DB, Pamer EG. Innate immune activation and CD4+ T cell priming during respiratory fungal infection.
Immunity. 2006 Oct;25(4):665-75. Epub 2006 Oct 5.