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Douglas B. Chrisey

Douglas Chrisey
Douglas B.
Chrisey
Ph.D.
Professor
Materials Science & Engineering
Rensselaer Polytechnic Institute
chrisd@rpi.edu

Unlimited potency makes stem cell therapy an exciting area of medical research, yet their properties in vitro and especially in vivo have not been comprehensively defined. Using a novel direct-writing method at RPI, we will fabricate combinatorial libraries of scaffold, biomolecule, and stem cell constructs, or niches, with single-cell spatial resolution. These tissue-constructs, with varying composition and geometry, will define stem cell properties, leading to custom-designed tissue replacements built with autologous cells. Professor Chrisey's laboratory is working to characterize effects of physical/biochemical stimuli on stem cells, and how these factors direct their differentiation and development and build stem cells into improved prototype tissue replacement constructs.

Select Publications: 

T.M. Patz, A. Doraiswamy, R.J. Narayan, N. Menegazzo, C. Kranz, B. Mizaikoff, Y. Zhong, R. Bellamkonda, J.D. Bumgardner, S.H. Elder, X.F. Walboomers, R. Modi, and D.B. Chrisey, Matrix assisted pulsed laser evaporation of biomaterial thin films, Materials Science and Engineering: C 27 (2007) 514.

B.R. Ringeisen, H. Kim, J.A. Barron, D.B. Krizman, D.B. Chrisey, S. Jackman, R.C.Y. Auyeung, and B.J. Spargo, Laser Printing of Pluripotent Embryonal Carcinoma Cells, Tissue Engineering 10, (2004) 483-491.

D.B. Chrisey, Materials Processing - The Power of Direct Writing, Science 289 (5481), (2000) 879-881.