Dr. Enikolopov studies signals that regulate distinct steps in the cascade converting stem cells into differentiated cells in different tissues focusing on the nervous system. Enikolopov's lab is generating new animal models to study stem cells in the brain and other adult tissues. These models enable the lab to isolate stem cells to examine the requirements of such cells for tissue maintenance, response to injury, repair, or transplantation. They developed a new approach for identifying and quantifying cellular targets of pro- and anti-neurogenic stimuli. The team is interested in how production of new neurons in the adult brain may be linked to antidepressant therapies and in neuronal and neuroendocrine circuits involved in mood regulation.
Gleiberman AS, Michurina T, Encinas JM, Roig JL, Krasnov P, Balordi F, Fishell G, Rosenfeld MG, Enikolopov G. Genetic approaches identify adult pituitary stem cells.
Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6332-7. Epub 2008 Apr 24. Erratum in: Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):11032
Encinas JM, Vaahtokari A, Enikolopov G. Fluoxetine targets early progenitor cells in the adult brain. Proc Natl Acad Sci U S A. 2006; 103:8233-8.
Mignone J, Kukekov V, Chiang AS, Steindler D, Enikolopov G. Neural stem and progenitor cells in nestin-GFP transgenic mice. J. Comp. Neurol. 2004; 469:311-24.