In the clinics of Orthodontics and Dentofacial Orthopedics, it is difficult to achieve treatment goals by moving teeth to the bone defects of the alveolar bone in patients with cleft palate and/or severe periodontal diseases. Stem cells offer great potential to help in building new bone for these clinical needs. Dr. Guan is focusing on identification of the candidate genes and pathways signaling differentiation of the mesenchymal stem cells and determination of the potential of mesenchymal stem cells to regenerate entire periodontal tissues. In the Guan laboratory, the long-term goal is, by manipulating stem cells, to reconstruct all the injured/damaged dental-craniofacial structures and to guide craniofacial growth and development.
Kramer PR, Kramer SF, Puri J, Grogan D, Guan G. Multipotent adult progenitor cells acquire periodontal ligament characteristics in vivo. Stem Cells Dev. 2009 Feb;18(1):67-76.
Guan G, Kerins CC, Bellinger LL, Kramer PR. Estrogenic effect on swelling and monocytic receptor expression in an arthritic temporomandibular joint model. J Steroid Biochem Mol Biol. 2005 Nov;97(3):241-50.
Kramer PR, Kramer SF, Guan G. 17 beta-estradiol regulates cytokine release through modulation of CD16 expression in monocytes and monocyte-derived macrophages. Arthritis Rheum. 2004 Jun;50(6):1967-75.