Dr. Hiroshi Mitsumoto is interested in research that involves patient care and works to find the cause and treatment of ALS. He participates in a number of clinical trials of ALS and helps his colleagues to lead major, NIH-funded clinical trials. He is interested in exercise in patients with ALS, in terms of improving muscle strength and function, but concurrently, he is involved in researching the effects of cycle exercise to experimentally generate oxidative stress in patients. He is participating in the nuclear transfer of ALS patient fibroblasts to fertilized human oocytes to generate the patient's ES cells.
Dimos JT, Rodolfa KT, Niakan KK, Weisenthal LM, Mitsumoto H, Chung W, Croft GF, Saphier G, Leibel R, Goland R, Wichterle H, Henderson CE, Eggan K. Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons. Science. 2008 Jul 31. [Epub ahead of print]
Hirano M, Angelini C, Montagna P, Hays AP, Tanji K, Mitsumoto H, Gordon PH, Naini AB, DiMauro S, Rowland LP. Amyotrophic lateral sclerosis with ragged-red fibers. Arch Neurol. 2008 Mar;65(3):403-6. Review.
Gwinn K, Corriveau RA, Mitsumoto H, Bednarz K, Brown RH Jr, Cudkowicz M, Gordon PH, Hardy J, Kasarskis EJ, Kaufmann P, Miller R, Sorenson E, Tandan R, Traynor BJ, Nash J, Sherman A, Mailman MD, Ostell J, Bruijn L, Cwik V, Rich SS, Singleton A, Refolo L, Andrews J, Zhang R, Conwit R, Keller MA; ALS Research Group. Amyotrophic lateral sclerosis: an emerging era of collaborative gene discovery. PLoS ONE. 2007 Dec 5;2(12):e1254.