Wnt signaling pathways, essential for embryogenesis, cell fate determination and pattern formation, are the most important signaling pathways for embryonic development. Inappropriate activation of Wnt signals produces cancer. Wnt canonical pathway is applied to control cell fate, whereas Wnt noncanonical pathway is used to regulate cell movement and tissue polarity. Professor Wang's research is focused on signaling maps in both pathways, particularly how cellular messengers are formed and how they regulate key molecules in these pathways. Understanding the signaling mechanism is critical for the success in manipulation of specific cell type differentiation and self-renewal of hESC.
Lee YN, Gao Y, Wang HY. Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3. Cell Signal. 2008 Feb;20(2):443-52. Epub 2007 Nov 17.
Ma L, Wang HY. Mitogen-activated protein kinase p38 regulates the Wnt/cyclic GMP/Ca2+ non-canonical pathway. J Biol Chem. 2007 Sep 28;282(39):28980-90. Epub 2007 Aug 7.
Gavi S, Yin D, Shumay E, Wang HY, Malbon CC. Insulin-like growth factor-I provokes functional antagonism and internalization of beta1-adrenergic receptors. Endocrinology. 2007 Jun;148(6):2653-62. Epub 2007 Mar 15.