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Iannis Aifantis

Iannis Aifantis
Iannis Aifantis, Ph.D. Assistant Professor of Pathology
New York University School of Medicine

The main focus of Professor Aifantis' laboratory is the study of the mechanisms of hematopoietic stem cell (HSC) differentiation and transformation. The research is focused on three signaling pathways:  Notch, Hedgehog (Hh) and SCF ubiquitin ligase signaling cascades, and their role in stem cell biology and function. Notch is a receptor/transcription factor initially identified in Drosophila melanogaster that is remarkably conserved during evolution. The studies have found that Notch not only affects stem cell commitment to the T lymphocyte lineage, but also transform the cells to induce fatal T cell acute lymphoblastic leukemia (T-ALL). Aifantis is studying the signaling pathways responsible for the oncogenic transformation of stem cells to identify cancer-initiating stem cells in T-ALL. Dr. Aifantis is using both loss and gain of function animal models to study the role of Hh signaling in HSC differentiation and self-renewal.

Select Publications: 

Aifantis, I., Raetz, E., Buonamici, S. (2008).  Molecular pathogenesis of T cell leukemia and lymphoma.  Nature Reviews Immunology, 8 (5):  380-390, 2008. 

Aifantis, Iannis; Vilimas, Tomas; Buonamici, Silvia. Notches, NFkappaBs and the making of T cell leukemia. Cell cycle. 2007; 6: 403.

El Andaloussi, Abdeljabar; Graves, Stephanie; Meng, Fanyong; Mandal, Malay; Mashayekhi, Mona; Aifantis, Iannis. (2006).  Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus. Nature Immunology. 7: 418-426, 2006.