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James L. Manley

James L.
Julian Clarence Levi Professor of Life Sciences
Columbia University

Dr. James L. Manley received a B.S. from Columbia University, his Ph.D. from Stony Brook/Cold Spring Harbor Labs, and did postdoctoral work at MIT. He has been in the Department of Biological Sciences at Columbia University since 1980, was Chair from 1995-2001 and is currently Julian Clarence Levi Professor of Life Sciences. His research interests center on understanding the mechanisms and regulation of gene expression in animal cells. His work has been supported by many grants, including an NIH MERIT Award, and he has published over 300 research articles on these topics. Dr. Manley has served on numerous editorial boards and review panels. He is a Fellow of the American Academy of Microbiology, American Academy of Arts and Sciences and American Association for the Advancement of Science, and a Member of the National Academy of Sciences.


Select Publications: 

Feng Y, Valley MT, Lazar J, Yang AL, Bronson RT, Firestein S, Coetzee WA, Manley JL. SRp38 regulates alternative splicing and is required for Ca(2+) handling in the embryonic heart. Dev Cell. 2009 Apr;16(4):528-38.

Shi Y, Di Giammartino DC, Taylor D, Sarkeshik A, Rice WJ, Yates JR 3rd, Frank J, Manley JL. Molecular architecture of the human pre-mRNA 3' processing complex. Mol Cell. 2009 Feb 13;33(3):365-76.

Vethantham V, Rao N, Manley JL. Sumoylation regulates multiple aspects of mammalian poly(A) polymerase function. Genes Dev. 2008 Feb 15;22(4):499-511.

David CJ, Manley JL. The search for alternative splicing regulators: new approaches offer a path to a splicing code. Genes Dev. 2008 Feb 1;22(3):279-85.

Shi Y, Manley JL. A complex signaling pathway regulates SRp38 phosphorylation and pre-mRNA splicing in response to heat shock. Mol Cell. 2007 Oct 12;28(1):79-90.

Li X, Manley JL. Cotranscriptional processes and their influence on genome stability. Genes Dev. 2006 Jul 15;20(14):1838-47. Review.