Dr. Palis' aim is to elucidate the cellular and molecular events underlying the initiation of hematopoiesis in the mammalian embryo by investigating the ontogeny of unipotential and multipotential hematopoietic progenitors and their origin from hemangioblast precursors. The Palis lab has identified an embryonic erythroid precursor with extensive self-renewal properties. These studies will ultimately produce insights into the ontogeny, regulation and expansion of the hematopoietic system and lead to improved treatment of marrow failure syndromes and leukemias.
England SJ, McGrath KE, Frame J, Palis J. Immature erythroblasts with extensive ex vivo self-renewal capacity emerge from the early mammalian fetus. Blood 117:2708-2717, 2011.
McGrath KE, Bushnell TP, Palis J. Multispectral imaging of hematopoietic cells: where flow meets morphology.
J Immunol Methods. 2008 Jul 31;336(2):91-7. Epub 2008 May 15. Review.
Tober J, Koniski A, McGrath KE, Vemishetti R, Emerson R, de Mesy-Bentley KK, Waugh R, Palis J. The megakaryocyte lineage originates from hemangioblast precursors and is an integral component both of primitive and of definitive hematopoiesis. Blood. 2007 Feb 15;109(4):1433-41. Epub 2006 Oct 24.
Huber TL, Kouskoff V, Fehling HJ, Palis J, Keller G. Haemangioblast commitment is initiated in the primitive streak of the mouse embryo. Nature. 2004 Dec 2;432(7017):625-30.