Professor Mao has expertise in several lineages of stem cells and their application in de novo formation or regeneration of tissues and organs. His research has shown that a synovial joint condyle can be formed in vivo with two stratified layers of cartilage and bone, both derived from a single population of mesenchymal stem cells. The Mao lab has demonstrated that synergistic actions of mesenchymal and hematopoietic stem cells lead to vascularized tissue and organ formation. The team has demonstrated that stem cells can be tracked in vivo and in real time using bioconjugated quantum dots and nanoparticles. Recently, they have shown that vascularized soft tissue can be generated from adult stem cells, providing the possibility to heal defects resulting from facial and breast cancer with stem cells.
Moioli, E.K., Clark, P.A., Sumner, D.R., Mao, J.J. (2008). Autologous stem cell regeneration in craniosynostosis. Bone 42: 332-340.
Stosich, M.S., Bastian, B., Marion, N.W., Clark, P.A., Reilly, G.C., Mao, J.J. (2007). Adipogenesis from human mesenchymal stem cells with engineered neovascularization. Tissue Engineering 13: 2881-2890.
Moioli EK, Hong L, Guardado J, Clark PA, Mao JJ. (2006). Sustained release of TGFbeta3 from PLGA microspheres and its effect on early osteogenic differentiation of human mesenchymal stem cells. Tissue Eng. 12(3):537-46.