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John M. Canty

John Canty
John M.
Albert & Elizabeth Rekate Professor of Medicine
Division of Cardiovascular Medicine
State University of New York at Buffalo

Dr. Canty heads the University's Center for Research in Cardiovascular Medicine. The center conducts translational research in patients with coronary artery disease as well as in animal models of chronic ischemic heart disease. The team is doing pioneering work investigating the mechanisms involved in sudden cardiac death, a condition caused by a catastrophic disruption in heart rhythm resulting in ventricular fibrillation. Other areas of investigational strength include the development of gene transfer and adult stem cell therapy treatments for ischemic heart disease and the implementation of high-throughput molecular biological approaches to identify mechanisms of acquired cardiovascular disease.

Select Publications: 

Suzuki G, Iyer V, Cimato T, Canty JM Jr. Pravastatin improves function in hibernating myocardium by mobilizing CD133+ and cKit+ bone marrow progenitor cells and promoting myocytes to reenter the growth phase of the cardiac cell cycle. Circ Res. 2009 Jan 30;104(2):255-64, 10p following 264.

Duan X, Young R, Straubinger RM, Page B, Cao J, Wang H, Yu H, Canty JM, Qu J. A straightforward and highly efficient precipitation/on-pellet digestion procedure coupled with a long gradient nano-LC separation and Orbitrap mass spectrometry for label-free expression profiling of the swine heart mitochondrial proteome. J Proteome Res. 2009 Jun;8(6):2838-50.

Jing D, Parikh A, Canty JM Jr, Tzanakakis ES. Stem cells for heart cell therapies. Tissue Eng Part B Rev. 2008 Dec;14(4):393-406.

Leiker M, Suzuki G, Iyer VS, Canty JM Jr, Lee T. Assessment of a nuclear affinity labeling method for tracking implanted mesenchymal stem cells. Cell Transplant. 2008;17(8):911-22.

Lin H, Shabbir A, Molnar M, Yang J, Marion S, Canty JM Jr, Lee T. Adenoviral expression of vascular endothelial growth factor splice variants differentially regulate bone marrow-derived mesenchymal stem cells. J Cell Physiol. 2008 Aug;216(2):458-68.

Lynch P, Lee TC, Fallavollita JA, Canty JM Jr, Suzuki G. Intracoronary administration of AdvFGF-5 (fibroblast growth factor-5) ameliorates left ventricular dysfunction and prevents myocyte loss in swine with developing collaterals and ischemic cardiomyopathy. Circulation. 2007 Sep 11;116(11 Suppl):I71-6.

Vacanti V, Kong E, Suzuki G, Sato K, Canty JM, Lee T. Phenotypic changes of adult porcine mesenchymal stem cells induced by prolonged passaging in culture. J Cell Physiol. 2005 Nov;205(2):194-201