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John Schimenti

Professor of Genetics
Center for Vertebrate Genomics
Cornell University

John Schimenti is a Professor of Genetics at Cornell with a primary appointment in the Dept. of Biomedical Sciences and an adjunct appointment in the Dept. of Molecular Biology and Genetics. He also serves as Director of the Center for Vertebrate Genomics at Cornell.

Dr. Schimenti received a B.A. from Rutgers College with majors in English and Biological Sciences in 1981, and his Ph.D. in Developmental Biology from the University of Cincinnati in 1985. After a postdoctoral fellowship with Lee Silver at Princeton studying mouse genetics, he became an Assistant Professor in the Dept. of Genetics at Case Western Reserve Univ. in 1987. There, Dr. Schimenti received the Searle Scholars Award, a Basil O'Connor award from the March of Dimes, and was named a Presidential Young Investigator by the National Science Foundation. In 1992, he moved to The Jackson Laboratory in Bar Harbor, Maine, where he was a Senior Staff Scientist before relocating to Cornell in 2004.

Dr. Schimenti has served as a permanent member of the Eukaryotic Genetics review panel at NSF, the Mammalian Genetics study section at NIH, the Secretariat of the International Mammalian Genome Society, the Scientific Advisory boards of a biotech company, and the Academia Sinica mouse mutagenesis program in Taiwan. He is on the editorial board of four scientific journals. His research on the genetics of fertility, development, iPS cells, and cancer in mice is currently funded by grants from the National Institutes of Health and NYSTEM.

Select Publications: 

Bolcun-Filas E, Rinaldi VD, White ME, Schimenti JC. Reversal of female infertility by Chk2 ablation reveals the oocyte DNA damage checkpoint pathwayScience. 2014 Jan 31;343(6170):533-6.

Mihola O, Trachtulec Z, Vlcek C, Schimenti JC, Forejt J. A mouse speciation gene encodes a meiotic histone H3 methyltransferase. Science. 2009 Jan 16;323(5912):373-5.

Mu W, Wang W, Schimenti JC. An allelic series uncovers novel roles of the BRCT domain-containing protein PTIP in mouse embryonic vascular development. Mol Cell Biol. 2008 Oct;28(20):6439-51.

Philipps DL, Wigglesworth K, Hartford SA, Sun F, Pattabiraman S, Schimenti K, Handel M, Eppig JJ, Schimenti JC. The dual bromodomain and WD repeat-containing mouse protein BRWD1 is required for normal spermiogenesis and the oocyte-embryo transition. Dev Biol. 2008 May 1;317(1):72-82.

Ward JO, Reinholdt LG, Motley WW, Niswander LM, Deacon DC, Griffin LB, Langlais KK, Backus VL, Schimenti KJ, O'Brien MJ, Eppig JJ, Schimenti JC. Mutation in mouse Hei10, an E3 ubiquitin ligase, disrupts meiotic crossing over. PLoS Genet. 2007 Aug;3(8):e139.