Professor Dordick's lab is interested in developing high-throughput tools for stem cell research. This relates to the development of cell microarrays that can be used to screen small molecules and growth factors for stem cell expansion and differentiation. Dordick and colleagues are developing methods to study millions of stem cells on devices the size of a standard microscope slide. Ultimately, they aim to develop new compounds that can be used to selectively alter stem cell physiology and evaluate their use in therapeutics.
Fernandes TG, Kwon SJ, Lee MY, Clark DS, Cabral JM, Dordick JS. On-chip, cell-based microarray immunofluorescence assay for high-throughput analysis of target proteins. Anal Chem. 2008 Sep 1;80(17):6633-9. Epub 2008 Jul 26.
Lee MY, Kumar RA, Sukumaran SM, Hogg MG, Clark DS, Dordick JS. Three-dimensional cellular microarray for high-throughput toxicology assays.
Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):59-63. Epub 2007 Dec 26.
Shang W, Nuffer JH, Dordick JS, Siegel RW. Unfolding of ribonuclease A on silica nanoparticle surfaces. Nano Lett. 2007 Jul;7(7):1991-5. Epub 2007 Jun 9. Review.