The interests of Dr. Kateri Moore's laboratory are focused on a cellular and molecular understanding of the hematopoietic stem cell niche. Previously, Moore's lab developed a molecular profile of an in vitro surrogate stem cell niche and established the Stromal Cell Database containing this data. From this profile they have identified many candidate molecular mediators of hematopoiesis that may be clinically relevant in manipulating stem cell populations in vitro prior to in vivo transplantation therapy. The lab is also using genetically modified mice as model systems to both manipulate and visualize stem cells in vivo under normal homeostasis and after perturbation.
Chateauvieux S, Ichante JL, Delorme B, Frouin V, Pietu G, Langonne A, Gallay N, Sensebe L, Martin MT, Moore KA, Charbord P. Molecular profile of mouse stromal mesenchymal stem cells. Physiol Genomics. 2007 Apr 24;29(2):128-38. Epub 2006 Dec 19.
Moore KA, Lemischka IR. Stem cells and their niches.
Science. 2006 Mar 31;311(5769):1880-5. Review.
Hackney JA, Charbord P, Brunk BP, Stoeckert CJ, Lemischka IR, Moore KA. A molecular profile of a hematopoietic stem cell niche. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13061-6. Epub 2002 Sep 11.