Professor Simon's stem cell research has been linked to the production of therapies for the replacement and restoration of full thickness cutaneous, oral and ocular surface injuries. Simon and colleagues were the first to unequivocally demonstrate epidermal stem cell transplant and maintenance in a 6-year follow-up study of transplant patients. The Simon lab has since identified epidermal stem cell markers and have carried out phenotype studies of over 800 clones. Metabolic distinctions between the mesenchymal stem cells originating in subcutaneous fat and dermis have also been found and are being functionally evaluated. Finally, to facilitate translation of research into clinical practice, the lab is building a cGTP/ cGMP facility production of clinical grade materials.
Gao JG, Simon M. A comparative study of human GS2, its paralogues, and its rat orthologue. Biochem Biophys Res Commun. 2007 Aug 24;360(2):501-6. Epub 2007 Jun 26.
Singer AJ, Jurukovski V, Simon M, Ma JY, Protter A, Arura B, Soroff HS. The presence of B-type natriuretic peptide in burns and the responsiveness of fibroblasts to BNP: proof of principle. Acad Emerg Med. 2007 Jun;14(6):503-7. Epub 2007 Apr 19.
Singer A and Simon M. (2006). Wound healing and skin substitutes. In: Stem cell and genebased therapy: Frontiers in regenerative medicine, Battler A, Leor J (eds), London:Springer- Verlag, pp. 375-393.