Dr. Rosen is investigating stem cell therapies for cardiac arrhythmias, myocardial regeneration and cancer therapy. For arrhythmias, Rosen has developed hMSC-based pacemakers to create a more physiologic outcome than electronic pacemakers. For cardiac regeneration he has enhanced the ability of hMSCs to follow a cardiac lineage, thereby recovering increased mechanical function. In cancer research the Rosen lab has developed an hMSC-based siRNA delivery system to enhance therapeutic targeting strategies. Dr. Rosen's research incorporates hMSCs, cardiac stem cells and most recently, human embryonic stem cells as they seek the optimal cell type for each therapeutic need. All studies incorporate use of quantum dots as tracking agents.
Rosen MR, Brink PR, Cohen IS, Robinson RB. The utility of mesenchymal stem cells as biological pacemakers. Congest Heart Fail. 2008 May-Jun;14(3):153-6. No abstract available.
Rosen MR, Brink PR, Cohen IS, Danilo P Jr, Robinson RB, Rosen AB, Szabolcs MJ. Regenerative therapies in electrophysiology and pacing. J Interv Card Electrophysiol. 2008 Aug;22(2):87-98. Epub 2008 Mar 25.
Schuldt AJ, Rosen MR, Gaudette GR, Cohen IS. Repairing damaged myocardium: evaluating cells used for cardiac regeneration. Curr Treat Options Cardiovasc Med. 2008 Feb;10(1):59-72.