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Michael S. Goligorsky

Michael Goligorsky
Michael S.
M.D., Ph.D.
Medicine & Pharmacology
New York Medical College
Alvin I. Goodman Chair in Nephrology

Studies performed in the Goligorsky laboratory in the last five years have established a) the role of premature cell senescence in endothelial dysfunction; b) contribution of endothelial progenitor cells (EPC) to rescuing the kidney from ischemia/reperfusion injury; c) the pathways of EPC mobilization and engraftment post-ischemia; d) the role of renal resident mesenchymal stem cells in renoprotection; e) the role of glial cell-derived neurotrophic factor in stimulating migration and antiapoptotic properties of mesenchymal stem cells; f) proteomic analysis of the urine in recipients of kidney transplant. Currently, Dr. Goligorsky is exploring the mechanism whereby alarm signaling, an innate immune response, mobilizes stem cells to the post-ischemic tissue/organ, the mechanisms of premature senescense of stem cells, and the proteomic phenotype of dysfunctional endothethial cells and their progenitors.

Select Publications: 

O'Riordan E, TN Orlova, N Mendelev, D Patschan, R Kemp, PN Chander, R, Hu, G, Hao, SS Gross, RV Iozzo, V Delaney, MS Goligorsky. Urinary proteomic analysis of chronic allograft nephropathy. Proteomics - Clinical
. 2: 1025-1035, 2008

Patschan S, Chen J, Gealekman O, Krupincza K, Wang M, Shu L, Shayman JA, Goligorsky MS. Mapping mechanisms and charting the time course of premature cell senescence and apoptosis: lysosomal dysfunction and ganglioside accumulation in endothelial cells.  Am J Physiol Renal Physiol. 2008 Jan;294(1):F100-9. Epub 2007 Oct 10.

Kuo MC, Patschan D, Patschan S, Cohen-Gould L, Park HC, Ni J, Addabbo F, Goligorsky MS. Ischemia-Induced Exocytosis of Weibel-Palade Bodies Mobilizes Stem Cells.
J Am Soc Nephrol. 2008 Aug 20. [Epub ahead of print]