The Cairo laboratory is engaged in investigations of dendritic cell biology, T-cell regulatory cell immunology, NK cell therapeutics, cord blood stem cell biology and genomics of hematological malignancies. The Cairo clinical research team leads investigations in reduced intensity allogeneic stem cell transplantation, phase I therapeutics and chemoimmunotherapy of leukemias and lymphomas. Dr. Cairo has developed an experimental procedure that expands the use of umbilical cord blood, a rich source of stem and immune cells, in transplantation for childhood leukemia and solid tumor patients. The Cairo laboratory is also engaged in cord blood stem cell regeneration and applied therapeutics.
Cairo, M.S., Rocha, V., Gluckman, E., Hale, G., Wagner, J. Alternative allogeneic donor sources for transplantation for childhood diseases: unrelated cord blood and haploidentical family donors. Biology of Blood and Marrow Transplantation 2008; 14 (1):44-53.
van de Ven C, Collins D, Bradley MB, Morris E, Cairo MS. The potential of umbilical cord blood multipotent stem cells for nonhematopoietic tissue and cell regeneration. Experimental Hematology. 2007; 3512): 1753-1764.
Ayello, J., van de Ven, C., Fortino, W., Wade-Harris, C., Satwani, P., Baxi, L., Simpson, L.L., Sanger, W., Pickering, D., Kurtzberg, J., and Cairo, M.S. Characterization of cord blood natural killer and lymphokine activated killer lymphocytes following ex vivo cellular engineering. Biology of Blood and Marrow Transplantation 2006: 12:608-622.