Periodontitis is a chronic inflammatory disease that damages the periodontal tissues and thus is the main cause for the loss of teeth. Professor Cho's research has focused on development of an effective, reliable and reproducible stem cell therapy capable of achieving periodontal regeneration. The Cho lab proposes to isolate, expand in vitro and transplant autologous hair follicle bulge stem cells, as they have an origin from neural crest like periodontal tissue-forming cells and the ability to differentiate into fibroblasts. Further, they are abundant and easily accessible by a minimally invasive surgery. Cho anticipates this adult stem cell therapy will ensure immediate repopulation of fibroblasts and thus successful periodontal regeneration.
Lee DS, Park JT, Kim HM, Ko JS, Son HH, Gronostajski RM, Cho MI, Choung PH, Park JC. Nuclear factor I-C is essential for odontogenic cell proliferation and odontoblast differentiation during tooth root development. J Biol Chem. 2009 Jun 19;284(25):17293-303.
Lee TY, Lee DS, Kim HM, Ko JS, Gronostajski RM, Cho MI, Son HH, Park JC. Disruption of Nfic causes dissociation of odontoblasts by interfering with the formation of intercellular junctions and aberrant odontoblast differentiation. J Histochem Cytochem. 2009 May;57(5):469-76.
Kim HS, Lee DS, Lee JH, Kang MS, Lee NR, Kim HJ, Ko JS, Cho MI, Park JC. The effect of odontoblast conditioned media and dentin non-collagenous proteins on the differentiation and mineralization of cementoblasts in vitro. Arch Oral Biol. 2009 Jan;54(1):71-9.
Park JC, Herr Y, Kim HJ, Gronostajski RM, Cho MI. Nfic gene disruption inhibits differentiation of odontoblasts responsible for root formation and results in formation of short and abnormal roots in mice. J Periodontol. 2007 Sep;78(9):1795-802.
Steele-Perkins G, Butz KG, Lyons GE, Zeichner-David M, Kim HJ, Cho MI, Gronostajski RM. Essential role for NFI-C/CTF transcription-replication factor in tooth root development. Mol Cell Biol. 2003 Feb;23(3):1075-84.
Herr Y, Matsuura M, Lin WL, Genco RJ, Cho MI. The origin of fibroblasts and their role in the early stages of horizontal furcation defect healing in the beagle dog. J Periodontol. 1995 Aug;66(8):716-30. Erratum in: J Periodontol 1995 Oct;66(10):915-23.
Matsuura M, Herr Y, Han KY, Lin WL, Genco RJ, Cho MI. Immunohistochemical expression of extracellular matrix components of normal and healing periodontal tissues in the beagle dog. J Periodontol. 1995 Jul;66(7):579-93. Erratum in: J Periodontol 1995 Oct;66(10):905-14.
Park JB, Matsuura M, Han KY, Norderyd O, Lin WL, Genco RJ, Cho MI. Periodontal regeneration in class III furcation defects of beagle dogs using guided tissue regenerative therapy with platelet-derived growth factor. J Periodontol. 1995 Jun;66(6):462-77.
Cho MI, Lin WL, Genco RJ. Platelet-derived growth factor-modulated guided tissue regenerative therapy. J Periodontol. 1995 Jun;66(6):522-30. Review.
Machtei EE, Cho MI, Dunford R, Norderyd J, Zambon JJ, Genco RJ. Clinical, microbiological, and histological factors which influence the success of regenerative periodontal therapy. J Periodontol. 1994 Feb;65(2):154-61.
Matsuda N, Lin WL, Kumar NM, Cho MI, Genco RJ. Mitogenic, chemotactic, and synthetic responses of rat periodontal ligament fibroblastic cells to polypeptide growth factors in vitro. J Periodontol. 1992 Jun;63(6):515-25.