My interest lies in viral hepatitis, especially Hepatitis B (HBV) and C (HCV) viruses. Infection of the liver with either of the viruses can ultimately cause liver failure for which organ transplantation may be the only answer. Re-infection of the transplanted organ is always a possibility. Our goals are to find alternate therapy in the form of cell transplantation where liver-like cells generated from stem/progenitor cells have been genetically modified to resist these virus infections. Our hypothesis is that by resisting viral infection these newly transplanted cells will repopulate the damaged liver and restore it to a healthy condition.
Yeh SW, Cavacini LA, Bhol KC, Lin MS, Kumar M, Duval M, Posner MR, Ahmed AR. Pathogenic human monoclonal antibody against desmoglein 3. Clin Immunol. 2006 Jul;120(1):68-75.
Liu F, Kumar M, Ma Q, Duval M, Kuhrt D, Junghans R, Posner M, Cavacini L. Human single-chain antibodies inhibit replication of human immunodeficiency virus type 1 (HIV-1). AIDS Res Hum Retroviruses. 2005 Oct;21(10):876-81.
Kong X, Hellermann GR, Patton G, Kumar M, Behera A, Randall TS, Zhang J, Lockey RF, Mohapatra SS. An immunocompromised BALB/c mouse model for respiratory syncytial virus infection. Virol J. 2005 Feb 8;2:3.
Kumar M, Kong X, Behera AK, Hellermann GR, Lockey RF, Mohapatra SS. Chitosan IFN-gamma-pDNA Nanoparticle (CIN) Therapy for Allergic Asthma. Genet Vaccines Ther. 2003 Oct 27;1(1):3.
Kong X, San Juan H, Kumar M, Behera AK, Mohapatra A, Hellermann GR, Mane S, Lockey RF, Mohapatra SS. Respiratory syncytial virus infection activates STAT signaling in human epithelial cells. Biochem Biophys Res Commun. 2003 Jun 27;306(2):616-22.
Kumar M, Behera AK, Lockey RF, Vesely DL, Mohapatra SS. Atrial natriuretic peptide gene transfer by means of intranasal administration attenuates airway reactivity in a mouse model of allergic sensitization. J Allergy Clin Immunol. 2002 Dec;110(6):879-82.
Behera AK, Kumar M, Lockey RF, Mohapatra SS. Adenovirus-mediated interferon gamma gene therapy for allergic asthma: involvement of interleukin 12 and STAT4 signaling. Hum Gene Ther. 2002 Sep 20;13(14):1697-709.
Kumar M, Behera AK, Lockey RF, Zhang J, Bhullar G, De La Cruz CP, Chen LC, Leong KW, Huang SK, Mohapatra SS. Intranasal gene transfer by chitosan-DNA nanospheres protects BALB/c mice against acute respiratory syncytial virus infection. Hum Gene Ther. 2002 Aug 10;13(12):1415-25.