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Program News and Releases
Electrical Stimulation Provides Conditioning Cues for Generation of Mature Heart Muscle Cells from Human Pluripotent Stem Cells
Researchers led by Gordana Vunjak-Novakovic, the Mikati Foundation Professor of Biomedical Engineering and Medical Sciences at Columbia University, have for the first time demonstrated that electrical conditioning of stem cell-derived cardiomyocytes in three-dimensional culture promotes cardiomyocyte maturation. The therapeutic success of human stem cell-derived cardiomyocytes critically depends on their ability to respond to and integrate with the surrounding electromechanical environment. Dr. Vunjak-Novakovic’s team showed that cardiomyocytes adapt their autonomous beating rate to the frequency at which they were stimulated, an effect mediated by the emergence of a rapidly depolarizing cell population. This rate-adaptive behaviour is long-lasting and transferable to the surrounding cardiomyocytes. In summary, this exciting discovery sheds some light on more effective stem cell therapy of the heart by preconditioning human stem cell-derived cardiomyocytes with electrical stimulation.
Combination of Stem Cells and Gene Modifying Tools Provide Path to Vision Repair
Scientists led by Stephen Tsang and Vinit Mahajan used CRISPR/Cas9-based gene modification in patient-derived stem cells to repair a mutation that causes retinitis pigmentosa.
The Vascular Niche Controls Lung Repair
Bi-Sen Ding and Shahin Rafii explore the role of lung endothelial cells in response to damage.
Expert Panel Assesses NYSTEM Program
NYSTEM: Capitalizing on Opportunities and Confronting Challenges, a Report by the NYSTEM External Review Panel
Lorenz Studer Profiled in The Scientist
Dr. Lorenz Studer, M.D., of Memorial Sloan Kettering Cancer Center was recently profiled in The Scientist.
Improved Method to Convert Skin Cells to Dopamine Neurons
Jian Feng Publishes an Improved Method to Produce Dopamine Neurons From Patient Cells
NYSTEM Congratulates Lorenz Studer, Winner of MacArthur Foundation Fellowship for Pioneering Research Into Parkinson’s Disease
Cornell Stem Cell Modeling and Phenotyping Core offers new services
The Cornell Stem Cell Modeling and Phenotyping Core offers new services and a revised price list through its Stem Cell Pathology Unit.
A Protocol for Production of Neurons to Study Mental Illnesses
A new method from Jian Feng’s lab details conversion of fibroblasts to serotonergic neurons
New Research Indicates Path to Cell-Based Therapy for Liver Diseases
Drs. Namita and Jayanta Roy-Chowdhury demonstrated transplantation of hepatocyte-like cells differentiated from human iPS cells can reduce the effects of liver disease.