Professor Stackowiak's research focuses on potential treatments of neuronal degenerative conditions through activation of adult brain neurogenesis by endogenous stem cells (NSC). Stackowiak's laboratory has established a novel pathway that controls NSC development and nanotechnology-based gene therapy to promote in vivo neurogenesis. The goals are to identify molecular mechanisms for neurogenesis in the adult brain and to establish gene therapeutic approaches for controlling neurogenesis following stroke or hearing loss. The lab is studying pluripotent human embryonic stem cells (HES) for differentiation into different types of functional neurons, and strategies for integrating these cells in vivo for sensory processing, cognitive behavior and motor functions in our animal models.
Stachowiak MK, Maher PA, Stachowiak EK; Integrative nuclear signaling in cell development--a role for FGF receptor-1.; DNA Cell Biol; 2007 Dec; 26(12); 811-826
Klejbor I, Myers JM, Hausknecht K, Corso TD, Gambino AS, Morys J, Maher PA, Hard R, Richards J, Stachowiak EK, Stachowiak MK. Fibroblast growth factor receptor signaling affects development and function of dopamine neurons - inhibition results in a schizophrenia-like syndrome in transgenic mice. J Neurochem. 2006 Jun;97(5):1243-58. Epub 2006 Mar 8.
Sun W, Buzanska L, Domanska-Janik K, Salvi RJ, Stachowiak MK. Voltage-sensitive and ligand-gated channels in differentiating neural stem-like cells derived from the nonhematopoietic fraction of human umbilical cord blood. Stem Cells. 2005 Aug;23(7):931-45.