Dr. Tabar's laboratory works to develop novel human ES-based cell replacement strategies for the treatment of central nervous system disorders such as neurodegenerative disease and radiation injury models. The current areas of research are: therapeutic application of stem cells in animal models of neural disease; Parkinson's and Amyotrophic Lateral Sclerosis and radiation injury to the brain; animal models, cellular basis of radiation injury and replacement therapy via human ES cells.
Piao J, Major T, Auyeung G, Policarpio E, Menon J, Droms L, Gutin P, Uryu K, Tchieu J, Soulet D, Tabar V. Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitors Remyelinate the Brain and Rescue Behavioral Deficits following Radiation. Cell Stem Cell. 2015 Feb 5;16(2):198-210.
Funato K, Major T, Lewis PW, Allis CD, Tabar V. Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation. Science. 2014, Dec 19: 346(6216):1529-33.
Lee G, Kim H, Elkabetz Y, Al Shamy G, Panagiotakos G, Barberi T, Tabar V, Studer L. Corrigendum: Isolation and directed differentiation of neural crest stem cells derived from human embryonic stem cells. Nat Biotechnol. 2008 Jul;26(7):831. No abstract available.
Tabar V, Tomishima M, Panagiotakos G, Wakayama S, Menon J, Chan B, Mizutani E, Al-Shamy G, Ohta H, Wakayama T, Studer L. Therapeutic cloning in individual parkinsonian mice. Nat Med. 2008 Apr;14(4):379-81. Epub 2008 Mar 23.
Elkabetz Y, Panagiotakos G, Al Shamy G, Socci ND, Tabar V, Studer L. Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage. Genes Dev. 2008 Jan 15;22(2):152-65. Erratum in: Genes Dev. 2008 May 1;22(9):1257.