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Pamela Cowin

Pamela Cowin
Dermatology & Cell Biology
New York University School of Medicine

The Cowin Laboratory focuses on the role of beta-catenin during breast development and in breast cancer. The lab has developed a mouse expressing activated betacatenin in the mammary gland and showed that this induces precocious alveolar development and breast cancer. The work indicates that beta-catenin acts downstream of hormones to stimulate the proliferation of breast stem cells and the survival of their immediate progenitors. Cell-type specific activation of betacatenin regulates ductal/alveolar cell fate, expansion and the induction of distinct types of breast tumors. Dr. Cowin is investigating the relationship between specific stem/progenitor cell expansion and tumor phenotype, and characterizing novel breast stem cell biomarkers.

Select Publications: 

Zhang X, Podsypanina K, Huang S, Mohsin SK, Chamness GC, Hatsell S, Cowin P, Schiff R, Li Y. Estrogen receptor positivity in mammary tumors of Wnt-1 transgenic mice is influenced by collaborating oncogenic mutations.  Oncogene. 2005 Jun 16;24(26):4220-31.

Liu B.Y., Kim Y.C., Leatherberry V., Cowin, P., Alexander, C.M. Mammary gland development requires syndecan-1 to create a beta-catenin/TCF-responsive mammary epithelial subpopulation. Oncogene. 2003 Dec 18;22(58):9243-53.