For the past twenty years, Dr. Morse's research has focussed exclusively on gene regulation and chromatin structure in the budding yeast Saccharomyces cerevisiae. The Morse lab has very recently embarked on studies of how chromatin contributes to regulation of neural stem cell identity and differentiation, in collaboration with Dr. Sally Temple. These studies will focus on how Polycomb Group (PcG) proteins control chromatin structure and gene expression in murine neural stem cells with an emphasis on genome-wide approaches.
Lee W, Tillo D, Bray N, Morse RH, Davis RW, Hughes TR, Nislow C. A high-resolution atlas of nucleosome occupancy in yeast. Nat Genet. 2007 Oct;39(10):1235-44.
Morse RH. Transcription factor access to promoter elements. J Cell Biochem. 2007 Oct;102(3):560-70.