Stem cells in vivo reside in a complex microenvironment that presents them with numerous signals that regulate their behavior and functions. Understanding how these factors influence stem cell fate is a major challenge of stem cell biology. Designing strategies to control stem cell function is also critical for applications of stem cells in tissue engineering and regeneration. The aims of research efforts in the Kane group are to develop and apply tools for elucidating gene function in stem cells and to develop bioactive materials - soluble ligands, biofunctionalized surfaces, and three-dimensional scaffolds for controlling stem cell function.
Joshi A, Vance D, Rai P, Thiyagarajan A, Kane RS. The Design of Polyvalent Therapeutics. Chemistry - A European Journal. 2008 Jun 13. [Epub ahead of print]
Ashton RS, Banerjee A, Punyani S, Schaffer DV, Kane RS. Scaffolds based on degradable alginate hydrogels and poly(lactide-co-glycolide) microspheres for stem cell culture. Biomaterials. 2007 Dec;28(36):5518-25. Epub 2007 Sep 19.
Ashton, RS, Peltier J, Fasano C, O-Neill A, Leonard J, Temple S, Schaffer DV, Kane RS. Clonal Microarrays: High-Throughput Screening of Gene Function in Stem Cells. Stem Cells. 2007, 25, 2928.