The stem cell research in Professor Dziak's lab involves the use of bone marrow stem cells for regeneration of bone. In many cases where there is a large effect due to trauma and/or osteoporosis, there is also a deficit of precursor cells evolving from osteoprogenitor stem cells. In these situations, which occur quite frequently, the addition of a bone matrix scaffold to support endogenous repair is not sufficient for complete healing, and the addition of stem cells can greatly enhance the healing process. Their research has led to the development of a nanocalcium sulfate scaffold into which bone marrow stem cells can be incorporated to most effectively enhance bone regeneration and repair of a large defect.
Kamer AR, El-Ghorab N, Marzec N, Margarone JE 3rd, Dziak R. Nicotine induced proliferation and cytokine release in osteoblastic cells. Int J Mol Med. 2006 Jan;17(1):121-7.
Bateman J, Intini G, Margarone J, Goodloe S, Bush P, Lynch SE, Dziak R. Platelet derived growth factor enhancement of two alloplastic bone matrices. J Periodontol. 2005 Nov;76(11):1833-41.
Perinpanayagam H, Martin T, Mithal V, Dahman M, Marzec N, Lampasso J, Dziak R. Alveolar bone osteoblast differentiation and Runx2/Cbfa1 expression. Arch Oral Biol. 2006 May;51(5):406-15. Epub 2005 Oct 25.