Professor Rochford has been using SCID mice to examine B cell lymphomagenesis. Rochford is also interested in expanding this model to develop humanized SCID mice which support erythropoeisis and expansion of human red blood cells. With this model, the Rochford laboratory will test novel anti-malaria drugs in collaboration with Walter Reed Army Medical Center. There is currently no adequate animal model system for testing of anti-malaria drugs.
Hochreiter R, Ptaschinski C, Kunkel SL, Rochford R. Murine gammaherpesvirus-68 productively infects immature dendritic cells and blocks maturation. J Gen Virol. 2007 Jul;88(Pt 7):1896-905.
Banerjee P, Rochford R, Antel J, Canute G, Wrzesinski S, Sieburg M, Feuer G. Proinflammatory cytokine gene induction by human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 Tax in primary human glial cells.
J Virol. 2007 Feb;81(4):1690-700. Epub 2006 Nov 22.
Wu W, Vieira J, Fiore N, Banerjee P, Sieburg M, Rochford R, Harrington W Jr, Feuer G. KSHV/HHV-8 infection of human hematopoietic progenitor (CD34+) cells: persistence of infection during hematopoiesis in vitro and in vivo. Blood. 2006 Jul 1;108(1):141-51. Epub 2006 Mar 16.