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Suzanne Laychock

Pharmacology & Toxicology
State University of New York at Buffalo

The research interest of Professor Laychock's laboratory is understanding the cellular mechanisms regulating insulin secretion from beta cells of Islets of Langerhans of the pancreas, and the expansion of beta-cell populations to meet the needs for transplantation approaches to treatment of diabetes mellitus. The long-term goal of this work is to improve the survival and function of transplanted pancreatic islets by enhancing islet post-transplantation angiogenesis and beta-cell survival and mitogenesis. Laychock is attempting to establish culture conditions that reduce apoptotic potential and produce endothelial cell and beta-cell growth and organization in isolated islets. This research has direct applicability to islet beta-cell progenitor (stem cell) research since the identification and expansion of beta-cells is a high priority in anticipation of transplantation.

Select Publications: 

Tian J, Lei P, Laychock SG, Andreadis ST. Regulated insulin delivery from human epidermal cells reverses hyperglycemia.  Mol Ther. 2008 Jun;16(6):1146-53. Epub 2008 Apr 22.

Lei P, Ogunade A, Kirkwood KL, Laychock SG, Andreadis ST. Efficient production of bioactive insulin from human epidermal keratinocytes and tissue-engineered skin substitutes: implications for treatment of diabetes.
Tissue Eng. 2007 Aug;13(8):2119-31.

Laychock SG, Tian Y, Sessanna SM. Endothelial differentiation gene receptors in pancreatic islets and INS-1 cells.  Diabetes. 2003 Aug;52(8):1986-93.