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Timothy C. Wang

Timothy C.
Silberberg Professor of Medicine and Chief of Gastroenterology
College of Physicians and Surgeons
Director of Tumor Microenvironment Program Columbia University

Dr. Timothy C. Wang is the Silberberg Professor of Medicine and Chair of the Division of Gastroenterology. He received his MD from Columbia University, followed by clinical training at Washington University and Harvard/MGH. He was on the Harvard faculty for 11 years, and Associate Chief of GI at MGH prior to relocation to the University of Massachusetts in 2000 and then Columbia University in 2004 as Division Chief. His main interest has been in murine models of gastric cancer, and the role of stem cells in inflammation-associated cancer. Dr. Wang's laboratory reported that gastric cancer in murine models can originate from bone marrow-derived stem cells. More recently, his group has identified markers for human gastric cancer stem cells, and also demonstrated that gastric cancer can arise from resident tissue stem cells. As the leader of the Columbia University Tumor Microenvironment Network, he has investigated the importance of stromal cells and the stem cell niche in governing stem cell differentiation, and how this niche is altered in chronic inflammatory states that predispose to cancer. He is currently investigating the role of BM-derived fibroblasts and myeloid cells in carcinogenesis. Dr. Wang is a recipient of the AGA Funderberg Gastric Cancer Award and is the Editor of the first textbook on gastric cancer, The Biology of Gastric Cancer (Springer 2009). He is the Chair of the GCMB NIH study section, Chair of the AGA Future Trends Committee, Associate Editor for Gastroenterology, and Editor in Chief of Therapeutic Advances in Gastroenterology. He is the author of more than 160 original peer-reviewed publications

Select Publications: 

Bromberg J, Wang TC. Inflammation and cancer: IL-6 and STAT3 complete the link. Cancer Cell. 2009 Feb 3;15(2):79-80.

Quante M, Wang TC. Inflammation and stem cells in gastrointestinal carcinogenesis. Physiology (Bethesda). 2008 Dec;23:350-9. Review.

Tu S, Bhagat G, Cui G, Takaishi S, Kurt-Jones EA, Rickman B, Betz KS, Penz-Oesterreicher M, Bjorkdahl O, Fox JG, Wang TC. Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice. Cancer Cell. 2008 Nov 4;14(5):408-19.

Marrache F, Pendyala S, Bhagat G, Betz KS, Song Z, Wang TC. Role of bone marrow-derived cells in experimental chronic pancreatitis. Gut. 2008 Aug;57(8):1113-20.

Houghton J, Stoicov C, Nomura S, Rogers AB, Carlson J, Li H, Cai X, Fox JG, Goldenring JR, Wang TC. Gastric cancer originating from bone marrow-derived cells. Science. 2004 Nov 26;306(5701):1568-71.

Fox JG, Beck P, Dangler CA, Whary MT, Wang TC, Shi HN, Nagler-Anderson C. Concurrent enteric helminth infection modulates inflammation and gastric immune responses and reduces helicobacter-induced gastric atrophy. Nat Med. 2000 May;6(5):536-42.

Wang TC, Cardiff RD, Zukerberg L, Lees E, Arnold A, Schmidt EV. Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice. Nature. 1994 Jun 23;369(6482)