Professor Mittal's laboratory is interested in the analysis of BM-derived stem/ progenitor cells that contribute to cancer progression and metastasis. The lab will focus on the role of bone marrow-derived endothelial stem/progenitor cells in angiogenesis- mediated progression of primary tumors, initiation of metastasis and development of micrometastasis to macrometastases. The clinical translation of these cells will be evaluated with respect to both their prognostic and therapeutic value. The utility of specific bone marrow stem cell populations in regenerating ischemic heart and limbs will be studied.
Gao D, Nolan DJ, Mellick AS, Bambino K, McDonnell K, Mittal V. Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis. Science. 2008 Jan 11;319(5860):195-8.
Ciarrocchi A, Jankovic V, Shaked Y, Nolan DJ, Mittal V, Kerbel RS, Nimer SD, Benezra R. Id1 restrains p21 expression to control endothelial progenitor cell formation. PLoS ONE. 2007 Dec 19;2(12):e1338.
Nolan DJ, Ciarrocchi A, Mellick AS, Jaggi JS, Bambino K, Gupta S, Heikamp E, McDevitt MR, Scheinberg DA, Benezra R, Mittal V. Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization. Genes Dev. 2007 Jun 15;21(12):1546-58.