My main interests are in the molecular control of cell fate and homeostasis of resident progenitor and stem cells in the developing and adult human brain. Using genomics approaches we have begun to identify an array of signaling pathways which operate in the regulation of human neural progenitors. We are currently assessing the functional significance of these pathways using pharmacolgical and lentiviral based overexpression and shRNAi in vitro, and with in vivo models of CNS demyelination/remyelination.
Sim FJ, Windrem MS, Goldman SA. Fate determination of adult human glial progenitor cells. Neuron Glia Biol. 2009 Oct 7:1-11.
Sim FJ, Lang JK, Ali TA, Roy NS, Vates GE, Pilcher WH, Goldman SA. Statin treatment of adult human glial progenitors induces PPAR gamma-mediated oligodendrocytic differentiation. Glia. 2008 Jul;56(9):954-62.
Sim FJ, Keyoung HM, Goldman JE, Kim DK, Jung HW, Roy NS, Goldman SA. Neurocytoma is a tumor of adult neuronal progenitor cells. J Neurosci. 2006 Nov 29;26(48):12544-55.
Sim FJ, Lang JK, Waldau B, Roy NS, Schwartz TE, Pilcher WH, Chandross KJ, Natesan S, Merrill JE, Goldman SA. Complementary patterns of gene expression by human oligodendrocyte progenitors and their environment predict determinants of progenitor maintenance and differentiation. Ann Neurol. 2006 May;59(5):763-79.
Sim FJ, Goldman SA. White matter progenitor cells reside in an oligodendrogenic niche. Ernst Schering Res Found Workshop. 2005;(53):61-81. Review.
Sim FJ, Zhao C, Li WW, Lakatos A, Franklin RJ. Expression of the POU-domain transcription factors SCIP/Oct-6 and Brn-2 is associated with Schwann cell but not oligodendrocyte remyelination of the CNS. Mol Cell Neurosci. 2002 Aug;20(4):669-82