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Program News and Releases

Patient Cells Shed Light On Developmental Mechanisms Underlying Schizophrenia

A new research collaboration from scientists at the University at Buffalo and the Icahn School of Medicine at Mount Sinai identifies a role for Integrative Nuclear FGFR1 Signaling in schizophrenia

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Toward Personalizing Treatments of Gliomas

Testing TGF-β inhibition as a radiosensitizer in tumor explants points toward a future of personalized therapies

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A Developmental Program for Cell Cannibalism

Research from Jeremy Nance identifies cell cannibalism during development of C. elegans

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Molecular Checkpoint Decisions Made by Subverted Vascular Niche Transform Indolent Tumors into Chemoresistant Cancer Stem Cells

Vascular niche of tumor-associated vascular endothelial cells (TECs) can enable cancer stem cell aggressiveness.

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NYSTEM Releases Second Strategic Plan

ESSCB releases second Strategic Plan reviewing NYSTEM's accomplishments and setting forth objectives for the next phase of the program: "The New York State Stem Cell Science (NYSTEM) Program: A Report on Progress and a Vision for the Future."

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International Collaboration Produces Haploid Human Embryonic Stem Cells

An international collaboration between researchers in New York and Israel produces haploid human embryonic stem cells capable of normal differentiation.

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Electrical Stimulation Provides Conditioning Cues for Generation of Mature Heart Muscle Cells from Human Pluripotent Stem Cells

Researchers led by Gordana Vunjak-Novakovic, the Mikati Foundation Professor of Biomedical Engineering and Medical Sciences at Columbia University, have for the first time demonstrated that electrical conditioning of stem cell-derived cardiomyocytes in three-dimensional culture promotes cardiomyocyte maturation. The therapeutic success of human stem cell-derived cardiomyocytes critically depends on their ability to respond to and integrate with the surrounding electromechanical environment. Dr. Vunjak-Novakovic’s team showed that cardiomyocytes adapt their autonomous beating rate to the frequency at which they were stimulated, an effect mediated by the emergence of a rapidly depolarizing cell population. This rate-adaptive behaviour is long-lasting and transferable to the surrounding cardiomyocytes. In summary, this exciting discovery sheds some light on more effective stem cell therapy of the heart by preconditioning human stem cell-derived cardiomyocytes with electrical stimulation.

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Combination of Stem Cells and Gene Modifying Tools Provide Path to Vision Repair

Scientists led by Stephen Tsang and Vinit Mahajan used CRISPR/Cas9-based gene modification in patient-derived stem cells to repair a mutation that causes retinitis pigmentosa.

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The Vascular Niche Controls Lung Repair

Bi-Sen Ding and Shahin Rafii explore the role of lung endothelial cells in response to damage.

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Expert Panel Assesses NYSTEM Program

NYSTEM: Capitalizing on Opportunities and Confronting Challenges, a Report by the NYSTEM External Review Panel

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