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ESSCB Statement Regarding the Conduct of Human Embryonic Stem Cell (hESC) Research Involving Chimeras
On November 14, 2011, the ESSCB Funding Committee voted to adopt a Statement Regarding the Conduct of Human Embryonic Stem Cell (hESC) Research Involving Chimeras, which was developed and...
New Model Informed Consent Forms
ESSCB Model Informed Consent Forms On November 14, 2011, the ESSCB Funding Committee approved five model informed consent forms developed by the ESSCB Ethics Committee. The forms provide guidance...
Patient Cells Shed Light On Developmental Mechanisms Underlying Schizophrenia
A new research collaboration from scientists at the University at Buffalo and the Icahn School of Medicine at Mount Sinai identifies a role for Integrative Nuclear FGFR1 Signaling in schizophrenia
Toward Personalizing Treatments of Gliomas
Testing TGF-β inhibition as a radiosensitizer in tumor explants points toward a future of personalized therapies
A Developmental Program for Cell Cannibalism
Research from Jeremy Nance identifies cell cannibalism during development of C. elegans
Molecular Checkpoint Decisions Made by Subverted Vascular Niche Transform Indolent Tumors into Chemoresistant Cancer Stem Cells
Vascular niche of tumor-associated vascular endothelial cells (TECs) can enable cancer stem cell aggressiveness.
NYSTEM Releases Second Strategic Plan
ESSCB releases second Strategic Plan reviewing NYSTEM's accomplishments and setting forth objectives for the next phase of the program: "The New York State Stem Cell Science (NYSTEM) Program: A Report on Progress and a Vision for the Future."
International Collaboration Produces Haploid Human Embryonic Stem Cells
An international collaboration between researchers in New York and Israel produces haploid human embryonic stem cells capable of normal differentiation.
Electrical Stimulation Provides Conditioning Cues for Generation of Mature Heart Muscle Cells from Human Pluripotent Stem Cells
Researchers led by Gordana Vunjak-Novakovic, the Mikati Foundation Professor of Biomedical Engineering and Medical Sciences at Columbia University, have for the first time demonstrated that electrical conditioning of stem cell-derived cardiomyocytes in three-dimensional culture promotes cardiomyocyte maturation. The therapeutic success of human stem cell-derived cardiomyocytes critically depends on their ability to respond to and integrate with the surrounding electromechanical environment. Dr. Vunjak-Novakovic’s team showed that cardiomyocytes adapt their autonomous beating rate to the frequency at which they were stimulated, an effect mediated by the emergence of a rapidly depolarizing cell population. This rate-adaptive behaviour is long-lasting and transferable to the surrounding cardiomyocytes. In summary, this exciting discovery sheds some light on more effective stem cell therapy of the heart by preconditioning human stem cell-derived cardiomyocytes with electrical stimulation.
Combination of Stem Cells and Gene Modifying Tools Provide Path to Vision Repair
Scientists led by Stephen Tsang and Vinit Mahajan used CRISPR/Cas9-based gene modification in patient-derived stem cells to repair a mutation that causes retinitis pigmentosa.
The Vascular Niche Controls Lung Repair
Bi-Sen Ding and Shahin Rafii explore the role of lung endothelial cells in response to damage.