Dr. Fishman's laboratory is interested in understanding the development, function and pathophysiology of the heart's specialized conduction system (CCS). Toward that end, using transcriptional profiling we have recently identified a novel cell surface protein that appears to be uniquely expressed by cells contributing to the CCS network. The transcriptional circuitry that regulates the specification of these cells and mechanisms that regulate their organization into a functional network are being explored. In a related series of studies, we have established murine embryonic stem cells that harbor an alternative CCS-specific marker. We are using these cells to characterize the differentiation of ES cells into functional conduction system cells. Together, these approaches may provide additional insight into CCS biology and novel therapies for conduction system and arrhythmic diseases.
Pallante BA, Giovannone S, Liu FY, Zhang J, Liu N, Kang G, Dun W, Boyden PA, Fishman GI. Contactin-2 Expression in the Cardiac Purkinje Fiber Network. Circ Arrhythm Electrophysiol. 2010 Jan 28.
Kalcheva N, Qu J, Sandeep N, Garcia L, Zhang J, Wang Z, Lampe PD, Suadicani SO, Spray DC, Fishman GI. Gap junction remodeling and cardiac arrhythmogenesis in a murine model of oculodentodigital dysplasia. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20512-6. Epub 2007 Dec 11.
Rentschler S, Zander J, Meyers K, France D, Levine R, Porter G, Rivkees SA, Morley GE, Fishman GI. Neuregulin-1 promotes formation of the murine cardiac conduction system. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10464-9. Epub 2002 Jul 29.
Rentschler S, Vaidya DM, Tamaddon H, Degenhardt K, Sassoon D, Morley GE, Jalife J, Fishman GI. Visualization and functional characterization of the developing murine cardiac conduction system. Development. 2001 May;128(10):1785-92.