Dr. Goldman is engaged in a broad spectrum of research relative to gene and cell-based strategies for repairing the damaged or diseased nervous system. The Goldman lab is focused on targeting and mobilizing endogenous stem and progenitor cells of the adult brain and spinal cord. The lab is studying the biology of adult progenitor cells in systems as diverse as the songbird neostriatum and the adult human temporal lobe, and their potential therapeutic roles in a correspondingly varied range of disease models. Goldman's group is working on isolation and molecular characterization of different progenitor cell types of both the fetal and adult human central nervous system (CNS), isolation and telomerase immortalization of developmentally-restricted neuronal progenitor cells from fetal CNS, and generating experimental models of cell type-selective neurodegenerative diseases, such as Parkinson's, ALS, Huntington's and dementia.
Goldman SA, Schanz S, Windrem MS. Stem cell-based strategies for treating pediatric disorders of myelin.
Hum Mol Genet. 2008 Apr 15;17(R1):R76-83. Review.
Windrem MS, Schanz SJ, Guo M, Tian GF, Washco V, Stanwood N, Rasband M, Roy NS, Nedergaard M, Havton LA, Wang S, Goldman SA. Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouse.
Cell Stem Cell. 2008 Jun 5;2(6):553-65.
Shin S, Sun Y, Liu Y, Khaner H, Svant S, Cai J, Xu QX, Davidson BP, Stice SL, Smith AK, Goldman SA, Reubinoff BE, Zhan M, Rao MS, Chesnut JD. Whole genome analysis of human neural stem cells derived from embryonic stem cells and stem and progenitor cells isolated from fetal tissue.
Stem Cells. 2007 May;25(5):1298-306.